In vivo Targeted Drug Delivery to the Brain using MRI Guidance of Focused Ultrasound
نویسندگان
چکیده
Introduction The clinical application of chemotherapy to brain tumors has been severely limited because antitumor agents are typically unable to penetrate an intact blood-brain barrier (BBB). Nonlocalized diffuse opening of the BBB permits drugs to reach the brain but can have dose-limiting side effects. MRI-guided focused ultrasound (FUS) can be applied to the brain to temporarily disrupt the BBB in a targeted manner [1] and is thus an advantageous technique for drug delivery. In this study, we investigated the effect of FUS on the absorption of liposome-encapsulated doxorubicin in the rodent brain and the use of MRI to guide this procedure.
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